In 1538, he helped Shahrukh of Shirvan against the Safavids but without success so he retreated back to Shaki.
The next year he married Pari Khan Khanum, daughter of the Safavid Shah Tahmasp I.
In 1551 Tahmasp I started an invasion of Shaki along with the Georgian king Levan of Kakheti.
The result of the massive invasion was the death of Darvish Mohammad Khan and the devastation of the castles Galarsan-Gorarsan and Kish.
Khan's son Bagi beg was held as prisoner in Shah Tahmasp I's court.