[2] Founded first in 1921, the school was closed, reopened, renamed, and relocated until its move to its current location, Bullocky Point, in 1962.

The priority enrolment areas are: Bayview, Coconut Grove, Coonawarra, Cullen Bay, Darwin City, Fannie Bay, Larrakeyah, Ludmilla, Millner, Nightcliff, Parap, Rapid Creek, Stuart Park, The Gardens, The Narrows and Woolner.

[7] Darwin High School's subjects follow the South Australian Certificate of Education curriculum and include: Arts; Business, Enterprise & Technology; English & Humanities; Health & Physical Education; Languages; Mathematics; Sciences; and Cross Disciplinary.

[9] The school offers a program for students who excel in English literature and writing; the application includes submitting a folio of their work and taking a placement test.

[10] The specialised mathematics and science program, Centre For Excellence (C4E), uses the school's affiliation with Xrata and ConocoPhillips and their partnership with Charles Darwin University.

[15] The Vesteys tank has now been transformed into a multi-purpose gymnasium which now functions as an indoor court and field for basketball, volleyball, soccer, and badminton.

[16] In 2016, the Labor Government pledged to fund a new scientific, technological, engineering, arts and mathematics (STEAM) building to help facilitate the increasing growth and of students.

[17] The development of a STEAM building will help facilitate and grow the students learning, as well as enhance and cultivate the required skills needed for future employment in these demanding fields.