Daughter of Smoke and Bone received high reviews from critics such as Chelsey Philpot from The New York Times, and Universal Pictures has acquired the rights for a film adaptation.

[3] Karou, a 17-year-old art student living in Prague, goes about her daily life attending classes and hanging out with her best friend Zuzana, while simultaneously trying to evade her ex-boyfriend Kazimir.

While with Zuzana, Karou is summoned by Brimstone to do a job, which requires her to collect teeth - both of human and animal origin - from her world and bring them to him.

The perpetrators turn out to be an angel named Akiva and his, essentially brother and sister, Liraz and Hazael, who belong to a race of seraphim at war with the chimaera in their local Eretz.

Feeling uncomfortable with the thought of leaving her family, Karou ventures into Morocco to purchase human teeth from an old graverobber, Izil, who is burdened with a cursed angel, Razgut, on his shoulder.

While Karou is sealed off from Brimstone's workshop, all the portals in the human world leading to it are burned away by the seraph's black handprints.

Consumed by a desire to see her family again, Karou travels the world, taking the physical wishes from Brimstone's teeth dealers by force.

In a confrontation that takes place in public, exposing angels to the human world, Akiva sends Karou off to safety from his siblings.

In Akiva's flashbacks, the truth is unveiled - Brimstone's business was to build new bodies using the teeth he collects, by which means he was able to endlessly resurrect fallen chimaera soldiers in the war against the seraphim, and "Karou" is simply the human incarnation of a deceased chimaera - born into a human body using the baby teeth once mentioned by Izil.

Karou's original identity was that of Madrigal Kirin, a chimaera who once spared the life of Akiva when she found him on the battlefield, and subsequently fell in love and started an affair with the seraph.

At last, however, Akiva must also reveal to her that his previous efforts to end the seraphim-chimaera war was by destroying Brimstone's business, and that all Karou's chimaera family is dead.