It was established by the decision of Administration of the "Georgian Committee for assisting the Poor" (established in 1928) on November 30, 1932, as a departmental organization within the framework of cultural base of Jewish workers; it was officially founded by the order of People's Commissariat of Education of Georgia on November 23, 1933, under the title 'Jewish Historic-Ethnographic Museum'.
The museum building was constructed in the early 20th century; it is built of brick; polygonal from the outside and circular inside (with 3 apses), with two (big and little) domes mounted on 8 coupled reinforced-concrete pillars located along the perimeter; as a result of reconstruction the building has become three-storied, approximately 20 metres long and wide and 21 metres high.
1017 of the Government of Georgia of 30 November 1992 based on the submission of the Association for Georgian-Jewish Relations of the Georgian Academy of Sciences and named after David Baazov, the famous rabbi and public figure.
The return of materials belonging to the museum was stipulated by order No.654 of the president of Georgia of 2004, along with the completion of building reconstruction.
"Hebraic studies" – volume 5 of an important series (I-1940, II-1941, III-1945, IV-2006, V-2008) was published; expeditions to various regions of Georgia were carried out, exhibitions arranged; international conferences on the issues of the Georgian Jews, and on the history of Georgian-Palestinian and Georgian-Jewish relations, were held.