His most notable contribution in history is as one of those accused of the murder of Lord Darnley and one of the persons organising the escape of Mary Queen of Scots from Lochleven Castle.
[2] In January 1565 he replaced Henry Sinclair, Bishop of Ross as a Senator of the College of Justice, adopting the title Lord Ormond.
In February 1567 he was named in a placard nailed to Edinburgh Tolbooth next to St Giles Cathedral as one of the conspirators in the murder of Henry Stuart, Lord Darnley and his valet, William Taylor.
The placard also accused the Earl of Bothwell, James Balfour of Flisk (near Cupar), and "black" John Spens, Lord Condie.
[5] In May 1568 he was involved in helping Mary Queen of Scots escape from Lochleven Castle and fought for her at the Battle of Langside, alongside numerous Scottish noblemen.