[12] Edwards joined the Pennsylvania State University faculty as an Associate Professor of Chemical Engineering in 1995, where he continued to research ways to make medicine inhalable.

[15][16] Edwards left academia in 1998 when he and Langer founded Advanced Inhalation Research (AIR); the startup was purchased a year later by Alkermes for $114 million.

Sensory Cloud released a nasal inhalable product intended to reduce infected air droplets from viruses like SARS-CoV-2, a strain of coronavirus known to cause COVID-19.

[22][23] In a February 2021 study in the Proceedings of the National Academy of Sciences of the United States of America, Edwards and his colleagues posited that "exhaled aerosol increases with COVID-19 infection, age, and obesity".

[28][29][30] Major exhibitions by artists such as Mark Dion[31][32] and artist/engineer Chuck Hoberman[33][34] were shown, as well as innovations developed by Edwards, his associates, and his students.