Under Gobel's leadership, Methuselah has invested millions of dollars to support research and development in regenerative medicine,[3] and is actively involved in efforts to change how the public thinks about extending the healthy human lifespan.

The objective of this work was to identify any protective molecular adaptations within the species that may be relevant to age-related diseases, particularly cancer.iv In 2021, Methuselah contributed $1 million to Albert Einstein College of Medicine to fund the development of engineered replacement brain structures to correct age-related neurological damage without losing memories or self identity.v vi Gobel has directed Methuselah's investment in a variety of companies developing breakthrough technologies and clinical interventions in regenerative medicine.

He was responsible for multiple investments in cutting-edge security capabilities, including the VOXER iPhone app[14][15] and the world's first hand-held mass spectrometer (aka 'Tricorder')[16] He also conceived and co-designed the IdeaFactory, DHS’s innovation management system.

Using "wisdom of crowds" principles and bottom-up techniques to bring the experience and intelligence of 170,000 employees to bear on critical problems of security, efficiency and public service, IdeaFactory is featured on whitehouse.gov as an example of government innovation.

From 1996 to 2002, Gobel was president of Obvious Software LLC, a venture project to design and build the world’s first fully independent artificial intelligence robotic online professional stock trading system.