Born at Ballymoney, County Antrim, 26 April 1726, he was the son of Robert McBride, Presbyterian minister there, and brother of John MacBride; his mother's name before marriage was Boyd.
He joined, and read papers before, the Medico-Philosophical Society there (established in 1756), and after the death of Charles Smith in 1762 he became its secretary.
[1] In December 1767 Macbride made a discovery in the art of tanning, advocating the use of lime water in the process.
For this he was, on 31 March 1768, made an honorary member of the Dublin Society, which awarded him a silver medal on 14 April following.
On 14 November 1769 he petitioned the Irish House of Commons for aid in developing his invention, and on 19 Nov. a committee was appointed, which reported favourably; no support seems, however, to have been given.
[1] Macbride married, first, on 20 November 1753, Margaret Armstrong; and secondly, on 5 June 1762, Dorcas, widow of George Cumming.