[3] The highlight of his 2009 senior season was a four-reception day for fifty-three yards against the Alabama Crimson Tide in the 2009 SEC Championship Game.

[2] During his four-season college career, Nelson played in forty-four games, started fourteen, and made forty-six receptions for 630 yards (a 13.7-yard average) and seven touchdowns.

Nelson was the recipient of quarterback Tim Tebow's "jump pass" in the 2009 BCS National Championship Game which cemented the Gators' 24–14 victory over the Oklahoma Sooners.

Nelson had two consecutive touchdowns catches in the 2010 season from quarterback Ryan Fitzpatrick in games against Cleveland and Miami, in weeks 14 and 15.

Following the 2012 season, which was cut short after he tore his ACL in week 1, the Bills did not tender a new contract, and Nelson became an unrestricted free agent.

After catching a touchdown pass from Ryan Fitzpatrick, Nelson jogged along the sidelines until he found Reich.

[14] Nelson and his brothers have started a non-profit organization, I'mME, that focuses on ending the orphan cycle.