He was part of the Los Angeles Dodgers team that won the 2020 World Series, although he did not play a single game after deciding to sit out the COVID-19 pandemic shortened season.

[2] He attended Cooperstown Dreams Park as a teenager, and was a standout on the Blackman High School baseball and basketball teams.

[1] Still, frustrated with his college workload, Price almost quit baseball to work at a McDonald's in his hometown but was talked out of it by his coach, Tim Corbin.

In the summer of 2006, Price helped the United States take home the gold medal in the World University Baseball Championship held in Cuba.

After the contract was approved by MLB, he was added to the Devil Rays 40-man roster before being optioned to the minor leagues to begin his career.

Price made his spring training debut against the Yankees, hitting the first batter he faced, Francisco Cervelli, and striking out the next three in one inning of work.

[8] Price was first assigned to pitch for the Vero Beach Devil Rays of the Class A-Advanced Florida State League.

[9] On May 30, 2009, Price collected his first major league regular-season win with a 5–2 victory over the Minnesota Twins in which he struck out 11 batters in under 6 innings.

[10] In the 2013 American League Wild Card tie-breaker against the Texas Rangers, Price pitched a complete game to lead the Rays into the postseason.

[18] On July 31, Price was traded to the Detroit Tigers in a three-team deal that sent Drew Smyly, Nick Franklin and Willy Adames to the Tampa Bay Rays, and Austin Jackson to the Seattle Mariners.

[19] In his Tigers debut against the New York Yankees on August 5, Price pitched 8+2⁄3 innings, allowing three runs, striking out ten, and walking none.

Price is the first pitcher in the major leagues to lose a complete game, one-hitter or better, with no earned runs since Andy Hawkins lost a no-hitter for the New York Yankees on July 1, 1990.

Only three previous times in major league history had a pitcher allowed 12 hits in two innings or fewer, the others being Shawn Estes in 2003, Johnny Podres in 1963 and George Uhle in 1929.

[10] On September 28, the last day of the regular season, Price pitched 7+1⁄3 shutout innings against the Minnesota Twins, giving up four hits, striking out eight, and earning the 3–0 win, to help the Tigers clinch their fourth consecutive AL Central Division title.

[24] On January 16, 2015, Price and the Tigers avoided arbitration agreeing on a $19.75 million salary for the 2015 season, setting a record for the largest one-year deal for an arbitration-eligible player prior to free agency.

[27] Price pitched a scoreless fourth inning in the game, striking out two, and earning the win for the AL.[28] He entered the All-Star Break with a 9–2 record, 2.38 ERA and 115 strikeouts.

[10] On July 30, 2015, Price was traded to the Toronto Blue Jays for Daniel Norris, Matt Boyd and Jairo Labourt.

He threw 119 pitches in 8 innings, recording 11 strikeouts and a winning decision, while yielding only 3 hits, 2 walks, and 1 earned run in a 5–1 victory over the Minnesota Twins at Rogers Centre.

[31] He was scratched from his final start of the season on October 1, as the Blue Jays had clinched the AL East the previous day.

[10] During spring training prior to the 2018 season, Price said he wished he had handled the situation with Eckersley differently and said he knew he could win the fans back by pitching well.

[10] Price next started Game 2 of the World Series, holding the Dodgers to two runs on three hits and three walks in six innings while striking out five, and earning the win in a 4–2 Boston victory.

Although ace Chris Sale was available on full rest (albeit with a shoulder injury), Price started Game 5, with Alex Cora reasoning that a National League park could require a pinch hitter that would cause him to remove his starter early.

He was relieved in the eighth inning with Boston leading, 5–1; Joe Kelly and Sale got the final six outs to clinch the World Series victory.

[47][48][49] On October 31, prior to the Red Sox victory parade, Price announced that he would not exercise an opt-out clause in his contract, saying that he wants to win in Boston; "We did that this year, and I want to do it again.

"[50] In early November, the New York City chapter of the Baseball Writers' Association of America (BBWAA) announced Price as the Babe Ruth Award recipient, honoring MLB player with the best performance in the postseason.

[52] Prior to the season, Price announced that he was changing his uniform number from 24 to 10, a tribute to his son Xavier, since "X" represents the Roman numeral ten.

[55] Price was briefly on the paternity list in early August,[56] as his wife gave birth to their second child;[57] at the time, he had a 7–4 record with 3.86 ERA in 20 starts, with 123 strikeouts in 102+2⁄3 innings.

[10] On February 10, 2020, the Red Sox traded Price, Mookie Betts, and cash consideration to the Los Angeles Dodgers in exchange for Alex Verdugo, Connor Wong and Jeter Downs.

[60] In May 2020, Price announced he would donate $1,000 to each of the Dodgers minor league players in an effort to help offset their costs during the COVID-19 pandemic.

On May 27, Price struck out his former teammate and fellow Vanderbilt alum Curt Casali of the San Francisco Giants for his 2,000th career strikeout.