He has played more than 1,500 concerts worldwide, and lead roles in opera, theater and musicals such as Cyrano (Cyrano de Bergerac), Shylock (The Merchant of Venice), Othello (Othello), Nabucco (Nabucco), Don Quixote (Man of La Mancha), Richard III (Richard III), Napoleon Bonaparte, Escamillo (Carmen), Enrico (Lucia di Lammermoor), Amonasro (Aida), the title roles of Don Giovanni and Rigoletto and starred in more than 100 films and TV series.

In 2017, David Serero was honored in Marquis Who's Who for outstanding achievement in the entertainment world and for his contribution for the betterment of contemporary society.

In 2019, he is named one of the top most influential Moroccans by airline Royal Air Maroc,[3] and received the 2019 Albert Nelson Marquis Lifetime Achievement Award.

He lived in New York from 2001 to 2003, where he studied singing with teachers from Broadway and from the Metropolitan Opera and acting at the HB Studio where he played Stanley from A Streetcar Named Desire by Tennessee Williams, Uncle Louie from Lost in Yonkers by Neil Simon and Marc Anthony from Julius Caesar by Shakespeare.

Serero moved to St Petersburg, Russia, to study at the Rimsky-Korsakov Music Conservatory where he made his debut as Scarpia (Tosca) and Germont (La traviata).

[6][5] In 2006, Serero made his European debut in the role of Escamillo (Carmen) at the Brasov Opera and returned the following year to perform the Four Villains (The Tales of Hoffmann).

His American debut took place the next year, when he performed as Alfio (Cavalliera rusticana) and Canio (Pagliacci) in Harrisburg, Pennsylvania.

[13] From September 2010 to June 2011, Serero performed at the Opera du Ranelagh in Paris, which included a concert with pianist Cyprien Katsaris.

[26][27] In November 2012, he performed in Paris in the lead role of Happy Mac[28] from Duke Ellington's only Broadway musical Beggar's Holiday.

[34] In April 2013 and 2014, he performed at the Royal College of Music in London for the Festival of Russian songs and was also a Jury member of the competition.

[40][41][42][43][44] In January 2014, he shared the cover of Theatre & Performance magazine in London with Barbra Streisand;[45] he released the album The Broadway Baritone, Volume 1, with the Prague Philharmonic Orchestra in April of that year.

[46] In April/May 2014, he performed a UK Tour in London at the Leicester Square Theatre,[47] Birmingham,[48] Liverpool[49] and at the Royal Northern College of Music in Manchester.

He was also starring in the French films Eva & Leon (Emilie Cherpitel) and Nous Trois ou Rien (Kheiron).

He performed lead roles in several films in New York such as The Kingdom of the Alley (as Marco) and Ring Ring (as the burglar) by Stephen Skeel, Super Paradise (as Adam the Rabbi) by Nour Matimush, Capicola (as Ralphie) by Mark Aiello, Laundry Day (as Angelo the mobster) by Jake Peterson, Ransom (as Mr Butler) by Brendan Duffy, There will come soft rains (Alonse) by Danielle Boyd and Amarena (Benny's father) by Andrew Abballe.

[61] He appeared in New York 180 (as Alfredo the tailor) by Hongkai Sun, Day to Night (as Saleem) in the horror film directed by Ana Pasisanos and produced by Larry Fessenden, Paisanos in Paris (as Francois) by Ernie Zahn, Near it all by Woody Lewis, Crime Scene: Do Not Cross (as Detective Jack) by Katie Huang, Speedy (as Ali) by Ameer Kazmi, Make it work / How we do it (as the executive) by Nicholas Bruckman with Adrienne C Moore, Gangs of New York – Blood Feuds for Discovery Channel by Andrea de Brito, Alice in America (as the Lottery investigator), Tango Shalom (as the cantor) by Gabriel Bologna, Again (as James) by Omar Salgado, Overload (as Sal) by Mark Aiello, The Redemption (as the violent father) by Steve Carmona, Sorry Charlie (as Adileh's father) by Lawrence Sharp, Hooligans (as the deli owner) by Patrick Lizza, Suddenly Rich (as the real estate agent) for TLC TV, Whistleblowers (CIA Agent) for Spike TV.

In March 2015, he played the parts of Christopher Sly & Vincentio from The Taming of the Shrew by Shakespeare at the New York Public Library.

[64] In June 2015, he played Off-Broadway the lead role of Shylock from The Merchant of Venice by Shakespeare at the Center for Jewish History in New York to critical acclaim[65] and is featured on Yahoo!

[67] He played the roles of Lewis the Dauphin and Robert Faulconbridge from King John by Shakespeare at the New York Public Library.

[69] In September, he performed for the New York Fashion Week and produces the debut album of Russian singer Zarina Maliti on his record label.

[71] On September 26 and 27, he performed two open air concerts on Times Square for Best of France with the presence of French President François Hollande.

The Jewish Week quoted David Serero's Shylock performances as one of the most notable along with Laurence Olivier, Al Pacino, Dustin Hoffman, Jacob Adler and Zero Mostel.

[81] He produces and releases the debut album Hunger Pains of Hip Hop artist Rob Cherry on his record label.

[91] David Serero enters the prestigious Who's Who America 2017 for demonstrating "outstanding achievements in the entertainment world and has contributed significantly to the betterment of contemporary society.

[93] He is a finalist of the Grand Prize 2017 edition of The French Entrepreneurs of Abroad (Les Français de l'étranger), in Arts & Culture category, by Air France.

[104] He performed an open air concert on 60th street and Park Avenue in New York for Bastille Day organized by the Fiaf.

[131] He releases his books Operation Odessa and From I Can't Breathe to Black Lives Matter: How George Floyd's Tragic Death changed America.

[132][133] He releases the following audio recordings: The Diary of a Madman by Gogol, The Megillah of Esther, The Greatest War Speeches of Napoleon Bonaparte, J'Accuse by Emile Zola.

[156] He returns Off-Broadway to star as Moses, adapts in English, directs, and produces the French musical American Premiere of "The Ten Commandments, The Musical" (Les Dix Commandements), studied with the French original cast member Daniel Levi,[157] and receives New York Cultural Commissioner Laurie Cumbo to attend the performance.

In New York he starred in: There will come soft rains by Danielle Boyd (2014), Capicola by Mark Aiello (2014), Laundry Day by Jake Peterson (2014), The Kingdom of the Alley and Ring Ring by Stephen Skeel (2014), Ransom by Brendan Duffy (2014), Amarena (filmed in Italian language) by Andrew Abballe (2014), Super Paradise by Nour Matimusha (2014), New York 180 by Hongkai Sun (2015), Paisanos in Paris by Ernie Zahn (2015), Near it all / How we do it by Nicholas Bruckman (2015), Crime Scene: Do Not Cross by Katie Huang (2015), Speedy by Ameer Kazmi (2015), Near it all by Woody Lewis (2015), Most Beautiful Island by Ana Paisanos (2015), The Redemption by Steve Carmona (2015), Sorry Charlie!

Serero has performed at concerts to benefit charities including UNICEF,[163] the Hadassah Hospital,[164] Meir Panim,[165] Jewish Deaf Association, Surgeons of Hope and Broadway Cares.