During this time, he also performed postdoctoral research in mouse models of lung cancer in the laboratory of Tyler Jacks at the Massachusetts Institute of Technology.
[5] In 2006, he moved to the Cambridge Research Institute, where he was a senior group leader and a professor of pancreatic cancer medicine.
In 2012, he took a position as a group leader and the deputy director of the Cancer Center at Cold Spring Harbor Laboratory.
[15] [16] During his postdoctoral training in the Jacks Laboratory, Tuveson learned how to engineer mouse models to study human cancer.
[17] When he started his own laboratory at the University of Pennsylvania, Tuveson developed some of the first genetically engineered mouse models to aid in the study of pancreatic cancer.
[20] He later partnered with Hans Clevers to develop pancreatic cancer organoids – tumor cells taken from a human patient and cultured in the laboratory as three-dimensional spheres.