David William Hopkins (October 31, 1897 – October 14, 1968) was a Republican U.S. Representative from Missouri; born in Troy, Doniphan County, Kansas.

Hopkins moved with his parents to Saint Joseph, Missouri in 1899.

He graduated from Graceland Academy, Lamoni, Iowa in 1916.

He then taught in the high schools of St. Joseph from 1922 until elected to Congress in 1928.

He was defeated in the election of 1932 and returned to private life as an insurance broker.