She won the Democratic primary unopposed,[6] and faced Republican state delegate Sid Saab in the general election.

[10] In October 2022, Saab filed a $2 million defamation lawsuit against Gile, alleging that some of her campaign literature contained false information about him and his business, including the suggestion that he is under federal indictment.

Gile, in a statement to Maryland Matters, called Saab's lawsuit a "distraction and a misuse of the legal system" and implied that his allegations were an act of desperation.

In January 2022, she called the Blueprint bill a "wonderful piece of legislation" but said that it did not address all the issues facing students and staff in public schools.

[18] Gile supports efforts to clean up pollution and runoff in the Chesapeake Bay and the Severn River.

[18] During her state senate campaign, Gile sought to capitalize on the issue of abortion rights following the Supreme Court's decision in Dobbs v. Jackson Women's Health Organization.