[8] From 2002 to 2006, Ostroff served as president of the UPN Network, a subsidiary of CBS, where she developed the popular reality series America's Next Top Model, along with other programs including Veronica Mars and Everybody Hates Chris.

[10] Beginning in 2006, Ostroff launched The CW broadcast network - a joint venture of CBS and Warner Bros. - and served as president of entertainment.

[12][13][14] Additionally, through its digital franchises, such as Vogue's "73 Questions" and WIRED's "Autocomplete Interview," CNE made 5,000 videos, garnering more than 11 billion views in 2017.

During Ostroff's time as Chief Content Officer, she focused on expanding the music streaming service into other forms of audio, primarily podcasts.

[17] She also negotiated exclusive podcast deals with Kim Kardashian West, Joe Rogan, Prince Harry and Meghan Markle.

[27] Ostroff is also one of the listed directors for the Tom Brady-backed digital NFT company Autograph[28] and is on the board of trustees for the Paley Center for Media.

[9] Ostroff has devoted herself over the years to work with several organizations such as A Place Called Home,[42] which helps children in South Central Los Angeles, the Independent School Alliance, and the American Jewish Committee.