De'Angelo Henderson Sr. (born November 24, 1992) is a former American football running back.

He played college football at Coastal Carolina University where he set an NCAA Division 1 record for touchdowns in consecutive games at 35.

[8][9][10] He became the sixth Coastal Carolina Chanticleer to be drafted and the first since Lorenzo Taliaferro and Matt Hazel in 2014.

[11] On September 24, against the Buffalo Bills in Week 3, Henderson recorded the first carry of his NFL career, a one-yard rush.

[12] In the regular season finale against the Kansas City Chiefs, he scored his first career professional touchdown, a 29-yard reception from quarterback Paxton Lynch.