DeAndre McDaniel (born November 26, 1987) is an American former college football player who was a safety for the Clemson Tigers.

McDaniel was signed as an undrafted free agent by the New Orleans Saints of the National Football League (NFL) to their practice squad in 2011.

McDaniel reportedly choked his girlfriend, punched her in the head and chest, and pushed her down a flight of stairs, causing her to seek medical attention for "serious bodily injury".

In 2010, McDaniel finished with 4 interceptions and 75 total tackles, including 12 in the Meineke Car Care Bowl.

On July 25, the day the NFL lockout ended, McDaniel announced on his Twitter account that he was signed by the New Orleans Saints.