[1] After the completion of his college football career, Grisham was signed by the Pittsburgh Steelers as a free agent after going undrafted in the 2009 NFL draft.

He spent the first 12 games of the 2009 NFL season on the Steelers practice squad, and was added to the 53-man roster on December 10, 2009 after an injury to another receiver.

Grisham made his first NFL reception on December 27, 2009 against the Baltimore Ravens for 14 yards, resulting in a first down.

He was then signed to their practice squad on September 6 and finished the season in that roster status.

Grisham signed a futures contract with the Denver Broncos in 2012, but was cut during the preseason.