DeSoto Lake is a lake within DeSoto National Wildlife Refuge, Harrison and Pottawattamie counties, Iowa and Washington County, Nebraska.

[1] Though it has the appearance of a natural lake it is man-made, created from a channel leading from the Missouri River in 1958.

[2] The lake creation was part of the overall development of the DeSoto National Wildlife Refuge.

[3] The lake is home to fish species such as black crappie, bluegill, channel catfish, flathead catfish, freshwater drum, largemouth bass, paddlefish, river carpsucker, sauger, walleye, white bass and yellow bass.

[1] Sport fishing on the lake is practiced, but subject to restrictions laid out by the states of Iowa and Nebraska.