De La Salle College was an independent Roman Catholic comprehensive single-sex secondary day school for boys, located in Ashfield, an inner-western suburb of Sydney, New South Wales, Australia.

Upon completion a year later, the school consisted of just three classrooms, and was located behind a boarding house that was to become a monastery for the six De La Salle brothers who were given the task of educating Catholic boys of the Ashfield parish.

With support from the parish and the Old Boys' Union, the principal of the time, Br Peter, began to expand the college.

[4] In 2008, five new science laboratories were completed and an air-conditioned multi-purpose hall with seating for up to 1500 and a full theatrical lighting and sound system was added.

[13] The college hall hosted the World Youth Day 2008 Journey of the Cross and Icon (JCI) in Sydney.

De La Salle College was a member of the Metropolitan Catholic Colleges Sports Association (MCC),[9] and competed in a range of sports including athletics, cricket, cross country, basketball, golf, rugby league, soccer, squash, swimming, tennis, touch football and volleyball.