St Bede's College is a Catholic secondary school for boys in the Melbourne suburb of Mentone.

The College was founded in 1938 by the De La Salle Brothers, a religious order based on the teachings of Jean-Baptiste de la Salle, and is a member of the Associated Catholic Colleges, the Council of International Schools and the International Boys' School Coalition.

The Order had purchased a property which included a Victorian homestead, "the McCristal Estate", that had been used by Mentone Girls Grammar School since the early 1920s.

The school was named after St. Bede the Venerable, a 7th-century Benedictine monk and priest, who spent his life teaching and writing at Jarrow Abbey, and who was the first English historian, famous for his publication of Ecclesiastical History of the English People.

Its ethos is that of an essentially middle class institution, with an emphasis on athleticism, religion, and discipline.