It is located in Bentleigh East, a suburb of Melbourne, Australia.

At the beginning of 2021, St James College was amalgamated into St Bede's College in Mentone, operating as a dedicated middle years campus.

St Bede's College is an inclusive community, driven by its Lasallian and Catholic ethos.

The College opened in 1970 in association with the De La Salle Brothers as St James Regional College, in order to serve six Catholic parishes in a fast-growing area of suburban Melbourne, and moved from temporary accommodations to the first buildings on its present campus in 1971.

[1] In early 2021, it became a campus of St Bede's College, Mentone, adopting its name and uniform.