[1] Most of the tracks on the album are medleys of, in the words of one author, "some of the Latino world's most memorable melodies.

The president of EMI Latin explained that both labels were trying to "reach every possible Placido fan out there, be it Latino or opera.

[6] The reviewer for The Washington Post praised the album as in some ways "the most satisfying record Domingo has made."

He also called Domingo "versatile as any musician in living memory" in part for the variety of recordings he had out at the time, including De Mi Alma Latina, the opera Parsifal, the classical symphonic album, Placido Domingo Sings and Conducts Tchaikovsky, and re-issues of Placido Domingo: Opera Classics and Verdi and Puccini Duets (with Leontyne Price).

At the time of the album's nomination, Billboard Magazine called De Mi Alma Latina underrated and predicted that Domingo might beat frontrunner and eventual winner Luis Miguel for his Segundo Romance.