De Soto is a census-designated place and unincorporated community in Clarke County, Mississippi, United States.

[4] De Soto was one of four principle towns established in Clarke County before the American Civil War.

Established along the Chickasawhay River before the arrival of the Mobile and Ohio Railroad, construction of housing in De Soto may have started as early as 1845 and by 1858 churches were being erected.

[5] A post office operated under the name De Soto from 1856 to 1978.

This Clarke County, Mississippi state location article is a stub.