De Soto High School is a public secondary school in De Soto, Kansas operated by De Soto USD 232 public school district, and serves students of grades 9 to 12.

The school is located near highway K-10 and Lexington Avenue on 91st Street.

Then the high school was moved to the present day City Hall and after the destruction of the original school the lower grades were moved to a building where district offices are today nearby the City Hall.

The high school was then expanded to include the present day community center which has one of the oldest sunken gyms still in use in the Midwest.

Years later, after overcrowding yet again, the high school was moved to its present location.