879721933ENSG00000104689ENSMUSG00000022074O00220Q9QZM4NM_003844NM_020275NP_003835NP_064671Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

[5][6] The protein encoded by this gene is a member of the TNF-receptor superfamily.

This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis.

[7] Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

[8] TNFRSF10A has been shown to interact with DAP3.