Debre Sina is a town in Amhara Region, Ethiopia.

The national highway reaches its highest point at 3120 meters above sea level.

Hydrologically, Debre Sina is located in the Afar endoreic basin.

Just to the west of Debre Sina, the Termaber pass crosses the continental divide into the Jamma River and Nile basin.

During the Italian occupation, the Termaber Pass was referred to as the "passo Mussolini".