DecodeME is an ongoing genome-wide association study searching for genetic risk factors for Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

The authors of a 2022 study suggested that research with more participants is needed to discover statistically significant differences.

It is being run as a partnership between Action for ME and the University of Edinburgh's MRC Human Genetics Unit, with Chris Ponting as chief investigator, and with £3.2 million in funding from the UK's Medical Research Council and the National Institute for Health Research.

[9][10] The investigators hope the study's findings will inform further research into the pathology of ME/CFS and potential treatments.

[14] In June 2023, DecodeME made changes to their data analysis methodology that allowed them to invite additional participants to give DNA.