Previous stations named Dedham Junction (1881–1884 and 1888–1899) and Rust Craft (1955–1977) were located near the modern site.

[3][4] In 1890 a short leg allowing Dedham-Islington travel for the Old Colony Railroad's Wrentham Branch was opened; trains using this route skipped Dedham Junction station.

[5][6] The station served the 1,500 employees of the Rust Craft Greeting Card Company plant, which opened that July.

[11] The development and station were opposed by some residents and local politicians concerned about additional traffic at the East Street rotary.

[1][12] The station initially failed to attract ridership; six weeks after opening, just 44 cars were counted in the parking lot one weekday.

[15][16] Boston–Foxboro service for events at Gillette Stadium was shifted to the Franklin Line in 1995, with Dedham Corporate Center as an intermediate stop.

[19]: 18  In late 2014, a kiss and ride dropoff lane was built on the north side of the station off Rustcraft Road.