The anime is set between the manga and video game storylines and follows the young recruit Shigure Daniel Kai who joins "Sleepers" in exploring Asylum which is inhabited by monsters called "Scarred" and human "Exiles", some of which have been affected by the Randolph Syndrome and are referred to as "Cultists".

The video game is set during the time when 540 million people lie in comas from Randolph syndrome and involve the sole survivor of a massacre that took place at a medical facility.

[1] A manga series with story by Norimitsu Kaihō and Makoto Fukami and art by Etorouji Shiono titled Deep Insanity: Nirvana has been serialized in Square Enix's seinen manga magazine Monthly Big Gangan from January 24, 2020 to March 25, 2023.

[5] An anime television series by Silver Link titled Deep Insanity: The Lost Child aired from October 13 to December 29, 2021, on Tokyo MX, MBS, BS11, TVA, and AT-X.

[12] Medialink licensed the series in Asia-Pacific (except Australia and New Zealand); they are streaming it on their Ani-One Asia YouTube channel and Bilibili.