They can be produced by extraction from several plant species belonging to three genera of the legume family, Fabaceae: Lonchocarpus, Derris, or Tephrosia.

Although "organic" (produced by nature) cubé resin is no longer considered environmentally safe.

However, high doses of deguelin are suspected of having negative effects on the heart, lungs and nerves.

The molecular mechanisms include the induction of apoptosis, mediated through AKT/PKB signaling pathways in malignant and premalignant human bronchial epithelia (HBE) cells, with only minimal effects on normal HBE cells.

Research has shown a correlation between intravenous deguelin and Parkinson's disease in rats.