The road runs through suburban neighborhoods and passes along the edge of Wilmington Airport along Airport Road before it provides access to a business park along Commons Boulevard.

It passes through suburban neighborhoods and then intersects DE 58 in a commercial area.

Past the DE 58 intersection, the route widens into a four-lane divided highway and forms the northwestern boundary of the Wilmington Airport, with residential areas on the opposite side of the road.

The route continues northeast and intersects Spruance Drive, which is the entrance road to the Delaware Air National Guard's New Castle Air National Guard Base to the east, before it comes to its terminus at US 202/DE 141.

[6][7] In 1985, the Commons Boulevard portion of the route was built and DE 37 was designated to run along its current alignment.