Her work, which incorporated images such as Elvis Presley, made her part of Buenos Aires' pop art scene.

Combining painting, set design, music and performance,[6] this exhibit has been identified by critic Nelly Perazzo as one of a series of "true landmarks" in forward-looking Argentinian art.

[7][8] In 1966 Cancela and Mesejean exhibited Nosotros Amamos ('We Love') at the Instituto Torcuato Di Tella, supporting acceptance of gender identity and popular culture.

One of the pieces, Roberto Plate's El Baño ('The Bathroom'), was removed by police because visitors had "decorated" it with anti-governmental graffiti.

Delia Cancela was one of several artists who removed their works and destroyed them, as an act of sympathy and in protest of the creation of a police state.

[14]: 288–294 While in Argentina in 1968, Cancela and Mesejean also held a fashion show Ropa con Riesgo ('Clothing with Risk') at ITDT.

[11] The fashions they designed were worn by celebrities such as Bianca Jagger,[16] and were featured on the cover of Vogue[16][17] and appeared in Harper's Bazaar,[18] and Queen.

[20] In 1975 Cancela and Mesejean returned to Paris, working with Yves Saint Laurent, Kenzo and the group Créateurs.