The Wabash Railroad opened it in 1929 as part of grade separation project which raised Delmar Boulevard over its tracks.

One such crossing was at Delmar Boulevard, in the West End, on the Wabash's route to Kansas City, Missouri.

The city would construct a new concrete viaduct to carry the boulevard, including streetcars, over the railroad tracks.

"[4] The new station opened to the public on August 1, 1929,[5] and for many years was an important part of St. Louis' transportation infrastructure and a catalyst for growth in the West End.

Passengers changing trains, such as between the Wabash Cannon Ball and the City of St. Louis, would transfer at Delmar Boulevard instead of Union Station.

By 1966 Delmar Boulevard, now owned by the Norfolk and Western Railway, was the only remaining outlying or "branch" passenger station in St. Louis.

[11] The station lay vacant until 1983 when the Norfolk and Western announced plans to demolish it, claiming that it was "structurally unsafe."

[13] Local businessman Joe Edwards bought the station in 2002; Washington University in St. Louis became a part-owner in 2016.