DMFI was founded in January 2019 in reaction to polling that showed that Democrats and younger voters were less supportive of Israel than previous generations.

[6][7] DMFI PAC endorsed more than 100 Democrats for House and Senate in the 2020 election cycle and ran attack ads opposing Bernie Sanders's candidacy during the 2020 primaries.

[11] Journalist Jonathan S. Tobin wrote that DMFI "played a not insignificant role in helping to undermine Sanders at a point in the campaign when he was the frontrunner and Biden seemed dead in the water".

[12] Political reporters Jonathan Allen and Amie Parnes credited DMFI PAC's primary ads with helping Biden secure the nomination.

[14] In the 2020 New York House election in district 15, DMFI PAC supported incumbent Eliot Engel joining Speaker Nancy Pelosi, Majority Whip Jim Clyburn, and the Congressional Black Caucus's political action committee.

[15][16][17][18][19][20] DMFI PAC made an endorsement in the 2021 Ohio 11th congressional district special election, in which the front-running candidates were progressive former State Senator Nina Turner and more moderate Democratic county councilwoman Shontel Brown.

[30][31] Journalist Daniel Marans of HuffPost said that "there's no question that DMFI played a pivotal role" in the election, which was held to replace Representative Marcia Fudge, now the U.S. Secretary of Housing and Urban Development.

[34] Warnock thanked DMFI PAC on Twitter for its endorsement, saying he would "stand for Israel's security" and "work to strengthen the alliance between our nations".

[44] In the 2022 U.S. Senate elections, the organization endorsed successfully reelected incumbents Catherine Cortez Masto and Raphael Warnock, and in an open race, Lieutenant Governor John Fetterman.

[48] In February 2023, DMFI PAC supported Jennifer McClellan in her successful campaign to become the first Black congresswoman in Virginia history after the death of Representative Donald McEachin triggered a special election.

[56] The PAC declared its support for incumbent Democratic Senators Bob Casey, Jacky Rosen, and Jon Tester, all of whom are facing competitive general election races.

[69][70] The Dispatch said the event was a “celebration” for the group after a successful primary season and wrote that "the consistent theme from the slate of speakers was this: Support for Israel is entirely consistent with liberal and progressive values.”[69] Elected speakers included Senator Ben Cardin, Governor Andy Beshear, and New York City Mayor Eric Adams, along with several U.S. House members.

[80][81] When the Biden White House released its National Strategy to Counter Antisemitism in May 2023, DMFI's President Mark Mellman strongly supported the plan in a statement and highlighted its inclusion of the IHRA definition.

[82][83] DMFI also backed the Nita Lowey Middle East Partnership for Peace Fund, which is intended to promote Israeli–Palestinian dialogue and support the Palestinian economy.

[84][85] DMFI supported the Iron Dome Supplemental Appropriations Act, which would provide Israel with $1 billion to restock its missile defense system that was depleted during the 2021 Israel–Palestine crisis.

[77][88] In his first call after assuming office, Foreign Minister Yair Lapid spoke to DMFI, during which he emphasized reinvigorating Israel's ties with the Democratic Party.

[92] DMFI called former president Trump's critical comments at the end of the 2022 election about the American Jewish community "insulting and ill-informed".

[93] DMFI was one of numerous organizations that called on UC Berkeley to rescind a provision that banned any speakers who support Israel or Zionism.

[96] Following the launch of coordinated attacks on border areas of Israel by Hamas on October 7, 2023, where Palestinian militants killed over 1,200 Israeli civilians, including women and children, and abducted around 250 civilians, including children, women and elderly people to the Gaza Strip, DMFI's President Mark Mellman noted that "the savagery of Hamas has moved the center of gravity in a pro-Israel direction" in American politics and felt that the movement of American liberals towards supporting Israel after the attack represented "a fundamental shift.

[2] Other prominent board members include Co-Chair Ann Lewis, former Secretary of Housing and Urban Development (HUD) Henry Cisneros, LGBTQ rights activist Meghan Stabler, and co-founder of JewBelong Archie Gottesman.