Dena Dubal is the David A. Coulter Endowed Chair in Ageing and Neurodegenerative Disease at University of California, San Francisco.
[9][10][11] She went on to show that the brains of healthy mice with extra Klotho were not only protected from neurodegeneration, but their cognitive abilities were enhanced.
[7] Alongside working on mouse models, in 2019, Dubal was the first to show that Klotho may protect people from Alzheimer's disease.
[15] Dubal has identified a biological mechanism – an epigenetic change on the X chromosome – that may give rise to why women live longer.
[2][16][17] She has shown that female mice with a particular pattern of sex hormones during their ovarian cycle are more likely to suffer from cognitive decline.