After graduating from college, Grayson enrolled in the Medical Scientist Training Program at Washington University School of Medicine,[5] where she earned an MD and a PhD in biochemistry and molecular cell biology.

[4][6] In 1999, The New York Times,[7] Science Daily and the Duke Chronicle[8] covered research on Ascaris hemoglobin[9] that Grayson had published in Nature, and stated, "The discovery may yield new therapies for diseases such as cancer, in which starving tumors of oxygen is a major therapeutic focus.

[15] Grayson then served as Vice President of Translational Sciences at 3-V Biosciences from 2008 to 2010,[14] where she oversaw the development of broad-spectrum antiviral drugs active against deadly viruses.

She served as the Vice President of Translational Sciences for AlloCure from 2011 to 2014, where she led research on a mesenchymal stem cell therapy for acute kidney injury.

[1] Since 2016, Grayson is a regular political commentator on Twitter, and asked onto media such as Fox News to speak on issues such as the Democrats proposal to reform elections.