[3] The Denio post office was originally north of the state line in Harney County, Oregon,[4] but the residents moved the building into Nevada in the mid-20th century.

The population of the CDP, which is entirely in Nevada, was 47 at the 2010 census;[5] additional development considered to be Denio extends into Oregon.

[6] Recreational activities in the Denio area include bird watching, photography, off-road vehicle use, fishing, recreational black opal mining, rockhounding, hunting, visiting the hot springs, and camping on the Sheldon National Wildlife Refuge.

[9] He worked in milling, mining, and farming in Nevada and California for 25 years before settling near the Oregon-Nevada border.

[9] After World War II a number of businesses relocated south of the state line to take advantage of Nevada's lack of an income tax and more liberal liquor, gambling, and prostitution laws.

[12] The Denio, Oregon, community was historically served by Crane Union, with the high school taking in several Basque Oregonians from there.