Denise Albe-Fessard (French pronunciation: [dəniz albəfesaʁ] ⓘ; 31 May 1916 – 7 May 2003), née Denise Gabrielle Henriette Marie Albe, was a French neuroscientist best known for her basic research into the central nervous system pain pathways, clarifying the distinction between lateral and medial thalamic pain processing.

[2] At the age of 10, she passed a competitive scholarship examination in her state primary school and received a free secondary education.

[2] She proceeded to earn an engineering degree in 1937 at School of Physique et Chimie de Paris, specializing in physics under the advice of her brother not to pursue medicine due to the struggles that women in that field faced.

After a month there, she quit and joined the Centre National de la Recherche Scientifique (CNRS) as a technical assistant for Daniel Auger, a plant electrophysiologist.

Working with amplifiers to measure electrical potentials of Nitella introduced Albe-Fessard to the limitations of recording bio-electric phenomena.