The Deposition of Christ is a painting by the Italian artist Agnolo di Cosimo, known as Bronzino, completed in 1545.

This portrayal of the Deposition, although it depicts all the characters typically shown when Jesus is being taken down from the cross, more correctly should be characterized as a Lamentation[2] and is an excellent example of late Mannerism or Maniera.

To preserve it after Granvelle's chapel was partially destroyed, the picture was housed in the Besançon city hall from 1793 until it became a part of the collection of the Musée des Beaux-Arts when the museum opened in 1834.

[5] After sending the original to Granvelle in 1545, Cosimo requested a copy for Eleonora's chapel that Bronzino painted eight years later in 1553.

[10] A fragment purportedly of the Saint Cosmas panel has recently been rediscovered, but it is suspected to be a forgery associated with art dealer Giulano Ruffini.

The Apostle John supports his back and is modeled on a youth holding up the body of Christ in a Deposition painted by Bronzino's teacher, Pontormo.

[14] Four holy women mourn on the left and another dressed in green peers over the Virgin's shoulder and stands out prominently because of her hand gesture and location in the center of the panel.

[2][15] Two of the three men in the background are named in the Gospel of John as the followers who took Jesus down from the cross and prepared his body for burial.

[2]In addition to embedding donor portraits and likenesses of themselves in their works, sixteenth-century Florentine artists were known to portray other artisans and associates in their paintings and sculptures.

[21] Elizabeth Pilliod has an alternative suggestion: the three companions from left to right are portraits of Giovambattista del Tasso (the architect who created Eleonora's chapel), Francesco di Ser Jacopo (a financial administrator for Cosimo), and Niccolò Tribolo (another artist in the service of the Medici).