Depot Creek is a river in Nipissing District in Northeastern Ontario, Canada.

[1] It is in the Saint Lawrence River drainage basin, is a tributary of Grand Lake on the Barron River, and lies entirely within Algonquin Provincial Park.

[2] The creek begins at an unnamed lake in geographic Edgar Township [2] and flows north to Francis Lake, then turns east to Pretty Lake.

It heads south, passes into geographic Barron Township, and reaches its mouth at Grand Lake.

This article related to a river in Northern Ontario, Canada is a stub.