She made six apparently uneventful voyages for the British East India Company (EIC) before she was sold in 1807 for breaking up.

Deptford was at Johanna on 7 August, reached Madras on 11 September and Diamond Creek on 14 October, and arrived at Kedgeree on 26 December.

Homeward bound, she was at Saugor on 6 March 1786, reached St Helena on 13 June, and arrived at Gravesend on 15 August.

Deptford reached Madras on 4 July and Bencoolen on 11 September; she arrived at Diamond Harbour on 1 November.

Homeward bound, she was at Saugor on 25 December and Madras on 2 January 1792, reached St Helena on 30 March, and arrived at Purfleet on 21 May.

[2] Deptford was part of a convoy of Indiamen that were bringing General Alured Clarke and his troops for the invasion of the Cape Colony.