[3][4] It came into existence when the London and Greenwich Railway opened its first section between Spa Road, Bermondsey, and Deptford on 8 February 1836, with an intermediate station at Southwark Park.

The replacement building was opened on Thursday 26 April 2012; this rebuild has made the station fully accessible.

A second entry/exit is now open since the refurbishment of the old carriage ramp is now complete; this new entrance is located on Platform 1.

Services at Deptford are operated by Southeastern and Thameslink using Class 376, 465, 466, 700 and 707 EMUs.

The typical off-peak service in trains per hour is:[5] Additional services, including trains to and from London Cannon Street via Sidcup call at the station during the peak hours.