[2] Derthona Basket was founded in 1955 in Tortona, a small town near Alessandria; however the club was later dissolved in 1962, only four years after obtaining the affiliation with the Italian Basketball Federation (FIP).

[5] On 22 October 2018, after three defeats in the first three games of the season, Derthona sacked Lorenzo Pansa and, on the following day, signed Marco Ramondino as the new head coach of the team.

On 29 June 2021, led by important American players like Jamarr Sanders and Jalen Cannon, as well as the young Italian pointguard Bruno Mascolo,[7] Derthona defeated Torino 3–2 in the national finals, reaching the Serie A for the first time in its history.

[9] During the first season in the top league, the team confirmed the backbone of the roster, but signed also good international players like J. P. Macura, Chris Wright, Tyler Cain and Mike Daum, as well as the Italian-Argentine veteran Ariel Filloy.

The Lions took part in the 2022 Italian Basketball Cup, defeating Trieste 94–82 and Virtus Bologna 94–82, reaching the finals, where it lost against Olimpia Milano 78–61.