Demoxytocin (INN) (brand names Sandopart, Odeax, Sandopral), also known as desaminooxytocin or deaminooxytocin, as well as 1-(3-mercaptopropanoic acid)oxytocin ([Mpa1]OT), is an oxytocic peptide drug that is used to induce labor,[1] promote lactation,[2] and to prevent and treat puerperal (postpartum) mastitis (breast inflammation).

[3] Demoxytocin is a synthetic analogue of oxytocin and has similar activities,[4] but is more potent and has a longer half-life in comparison.

[2][1] Unlike oxytocin, which is given via intravenous injection, demoxytocin is administered as a buccal tablet formulation.

[1] Labour was induced or stimulated after random allocation of the mothers to one of three oxytocics (prostaglandin E2 orally, oxytocin intravenously, or demoxytocin buccally).Using as models, the neurohypophyseal nonapeptide hormone oxytocin and its analogue deaminooxytocin, several directed routes to formation of sulfur-sulfur bridges have been developed and evaluated.

The efficacy of oral PGE2 tablets and buccal demoxytocin (resoriblets) for the induction of labor in cases of premature rupture of the membranes (PROM) after the 37th week of gestation has been evaluated in a prospective, randomized investigation of 193 women.