On October 1, the group embarked on the worldwide (excluding Africa, South America, and most Asia) Deserve the Future Tour with dates going into 2010.

After going on hiatus in 2010, each member of the band has expressed interest in reuniting to record a new album, with conflicting schedules being cited as the primary delay of a full-scale reunion.

In September 2022, Them Crooked Vultures reunited for a pair of performances at both London's Wembley Stadium and the Los Angeles Kia Forum, both as part of tribute shows in honour of Foo Fighters' late drummer Taylor Hawkins.

A collaboration between Josh Homme, John Paul Jones, and Dave Grohl was first publicly mentioned by Grohl in a 2005 interview with Mojo, in which he declared "The next project that I'm trying to initiate involves me on drums, Josh Homme on guitar, and John Paul Jones playing bass."

On November 9, Them Crooked Vultures started streaming their full album on their website, and also through a link to their mailing list with the title "Fuck Patience, Let's Dance."

On October 26, 2010, the song titled "Dead End Friends" was included as an on-disc track for the game Rock Band 3.

On February 6, 2010, the band performed the songs "Mind Eraser, No Chaser" (now the second single) and "New Fang" as musical guests on Saturday Night Live.

[17] In March, it was announced that the group were to play at The Royal Albert Hall in aid of The Teenage Cancer Trust[18] with support coming from Little Fish.

[22] A video was uploaded to the band's official YouTube channel entitled 'Fresh Pots' which NME claimed was filmed during recording for their follow-up album.

[23] Grohl clarified after the video's release that it was filmed a year prior, during the self-titled album's recording sessions.

[24] On November 12, 2010, in an interview with BBC 6 Music, John Paul Jones has confirmed that the band is ready to resume working on putting together new material for a fresh release, and will go into the studio very soon.

"[26] In December 2012, when asked about the band's future, Dave Grohl stated: "We've talked about it, I know that someday we'll get back together and do stuff, because we love playing with each other.

"[27] Grohl once again mentioned a possible reunion in an interview with Zane Lowe on Apple Music's Beats 1 radio station in June 2017.

[28][29] In an interview with The Guardian in August 2019, Grohl stated: "It's still hard to accept that I got to play in a band with [John Paul Jones].

"[31] In September 2022, the band reunited for two tribute shows dedicated to late Foo Fighters drummer Taylor Hawkins.