Nosbusch was born in Esch-sur-Alzette, Luxembourg to a Luxembourgish father and an Italian mother.

[1] She was a member of the youth drama group of the Lycée Hubert Clément of Esch-sur-Alzette (Luxembourg).

At twelve years old, she started working at Radio Luxemburg, and then did a show with Anke Engelke on ARD.

In 1984, she recorded a duet with Austrian singer Falco, "Kann es Liebe sein?".

[2] In 2021, she launched the production of the feature film Poison, an adaptation of Lot Vekemans' play,[2] starring Tim Roth and Trine Dyrholm.