Desloge (/dəˈloʊʒ/ də-LOHZH) is a city in St. Francois County, Missouri, United States.

A Desloge developed one of his claims just north of Bonne Terre and built a concentrating plant there.

In 1887, the land was cleared and company houses for his staff were constructed in an area referred to as "Desloge Town", just west of the present-day railroad tracks.

Here, Desloge sank a shaft and built a concentrating plant which began operations in 1892.

[6][7][8] Firmin Desloge II, who died in 1930, willed to his family the original 47 acres (190,000 m2) of the hand-dug pits of the original lead mining operations and the deeply rutted wagon tracks on a property.

[9] Desloge City Park in the center of town at Parkside and Walnut streets has an Olympic-size swimming pool, tennis courts, picnic tables, barbecue pits, amphitheater, walking/jogging path, and playground equipment.

Emergency calls are handled by the St. Francois County Joint Communications Center.

The City of Desloge Volunteer Fire Department, at 100 Chadrick Street, has a 2000 pumper truck.

The City of Desloge Public Works Department at 1000 East Chestnut Street oversees the Municipal Waterworks system, streets and alleys, trash removal, recycling, and city maintenance.

Free weekly trash pickup is no longer offered to Desloge residents, they are now forced to pay for the service.

The osteopathic Mineral Area Regional Medical Center in Farmington closed in January 2016.

[12] According to the United States Census Bureau, the city has a total area of 2.90 square miles (7.51 km2), all land.