Wortham is a census-designated place in St. Francois County, in the U.S. state of Missouri.

[2] Wortham was originally called "Cherrytown", and under the latter name was platted in 1904.

[4] A post office called Wortham was established in 1925 and remained in operation until 1969.

[5] An early postmaster, Ray Wortham, gave the community its name.

This Saint Francois County, Missouri state location article is a stub.