It is part of the St. Charles Parish Public School System and serves all students on the east bank of the Mississippi River from grades 9 through 12.

[6][7] Destrehan High School was dedicated on September 15, 1924, and the facility received 234 pupils in grades one through eleven.

On October 7, 1974, students were sent home early after racially motivated fights broke out in the school.

[10] A federal appeals court ruled Tyler did not receive a fair trial, but he was never retried and remained in prison until his release in May 2016.

Courses at the Satellite Center include: Advanced Television Broadcasting, Digital Media, Engineering Design, Interactive Media, Process Technology (PTEC), Health Care Exploration, Patient Care, Hotel-Restaurant and Tourism (HRT) Administration, Culinary Arts, and Students Teaching And Reaching (STAR).

[13] As of the 2018–2019 school year, the Satellite Center added courses in Instrumentation and Health Clinical.

Thus, the courses of Digital Media, Interactive Media, and Advanced Television Broadcasting were moved into the academic wing of the school district's brand new Rodney Lafon Performing Arts Center less than a block away from the Satellite Center.

[14] In 2017, Destrehan High School was one of thirty high schools world-wide to be named "world-leading learners" and to receive a fellowship based on academic excellence, and reducing the achievement gap between racial and socioeconomic groups and innovation.

The roof of the main building, which houses the administrative offices, the library and auditorium, collapsed.

The students attended Hahnville High School for an alternating-day schedule while repairs were being made.

The expansion increased seating capacity to 1,000 and a new auxiliary gym and elevated running track were built.

[18] To accommodate for larger student bodies, the school has had numerous building additions and wing expansions.

After removing the portable classrooms that Building L replaced, students in ROTC have access to a large yard space for practice.

[27] Those teams under head coach Stephen Robicheaux were part of a 30-game winning streak from 2007 to September 2009.

[36] The Destrehan Fighting Wildcats and Lady Cats track and field teams compete in District 7-5A in the LHSAA.